Cargando…

Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures

[Image: see text] Multitarget directed ligands (MTDLs) represent a promising frontier in tackling the complexity of multifactorial pathologies. The synergistic inhibition of monoamine oxidase B (MAO B) and acetylcholinesterase (AChE) is believed to provide a potentiated effect in the treatment of Al...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ekström, Fredrik, Gottinger, Andrea, Forsgren, Nina, Catto, Marco, Iacovino, Luca G., Pisani, Leonardo, Binda, Claudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919507/ https://www.ncbi.nlm.nih.gov/pubmed/35300078 http://dx.doi.org/10.1021/acsmedchemlett.2c00001

Ejemplares similares

Rational Redesign of Monoamine Oxidase A into a Dehydrogenase to Probe ROS in Cardiac Aging
por: Iacovino, Luca Giacinto, et al.
Publicado: (2020)

Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer’s disease
por: Yusufzai, Samina Khan, et al.
Publicado: (2018)

Halogenated Coumarin–Chalcones as Multifunctional Monoamine Oxidase-B and Butyrylcholinesterase Inhibitors
por: Rehuman, Nisha Abdul, et al.
Publicado: (2021)

Promising Non-cytotoxic Monosubstituted Chalcones to Target Monoamine Oxidase-B
por: Iacovino, Luca G., et al.
Publicado: (2021)

Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors
por: Oh, Jong Min, et al.
Publicado: (2020)

Latest advances in dual inhibitors of acetylcholinesterase and monoamine oxidase B against Alzheimer’s disease
por: Zou, Dajiang, et al.
Publicado: (2023)

Inhibition of Butyrylcholinesterase and Human Monoamine Oxidase-B by the Coumarin Glycyrol and Liquiritigenin Isolated from Glycyrrhiza uralensis
por: Jeong, Geum Seok, et al.
Publicado: (2020)

Novel C7-Substituted Coumarins as Selective Monoamine Oxidase Inhibitors: Discovery, Synthesis and Theoretical Simulation
por: Wang, Dong, et al.
Publicado: (2019)

Systemic lipopolysaccharide-mediated alteration of cortical neuromodulation involves increases in monoamine oxidase-A and acetylcholinesterase activity
por: Ming, Zhi, et al.
Publicado: (2015)

Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations
por: Sasidharan, Rani, et al.
Publicado: (2021)

Synthesis and Evaluation of Novel S-alkyl Phthalimide- and S-benzyl-oxadiazole-quinoline Hybrids as Inhibitors of Monoamine Oxidase and Acetylcholinesterase
por: Khan, Bilal Ahmad, et al.
Publicado: (2022)

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds
por: Stefanachi, Angela, et al.
Publicado: (2018)

Coumarin-Resveratrol-Inspired Hybrids as Monoamine Oxidase B Inhibitors: 3-Phenylcoumarin versus trans-6-Styrylcoumarin
por: Mellado, Marco, et al.
Publicado: (2022)

Monoamine Oxidases, Oxidative Stress, and Altered Mitochondrial Dynamics in Cardiac Ageing
por: Maggiorani, Damien, et al.
Publicado: (2017)

Broad‐Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve‐Agent‐Inhibited Acetylcholinesterase
por: Lindgren, Cecilia, et al.
Publicado: (2022)

An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet
por: Allgardsson, Anders, et al.
Publicado: (2017)

Monoamine Oxidase-A Occupancy by Moclobemide and Phenelzine: Implications for the Development of Monoamine Oxidase Inhibitors
por: Chiuccariello, Lina, et al.
Publicado: (2015)

Acetylcholinesterase and monoamine oxidase-B inhibitory activities by ellagic acid derivatives isolated from Castanopsis cuspidata var. sieboldii
por: Oh, Jong Min, et al.
Publicado: (2021)

ABUSE OF MONOAMINE OXIDASE INHIBITORS
por: Ananth, Jambur, et al.
Publicado: (1995)

Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B
por: Knez, Damijan, et al.
Publicado: (2020)

N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases
por: Bautista-Aguilera, Óscar M., et al.
Publicado: (2022)

Recent advances on the role of monoamine oxidases in cardiac pathophysiology
por: Kaludercic, Nina, et al.
Publicado: (2023)

Structure–Activity Relationships Reveal Beneficial Selectivity Profiles of Inhibitors Targeting Acetylcholinesterase of Disease-Transmitting Mosquitoes
por: Vidal-Albalat, Andreu, et al.
Publicado: (2023)

Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies
por: Naoi, Makoto, et al.
Publicado: (2022)

2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors
por: Legoabe, Lesetja J, et al.
Publicado: (2015)

Amphetamine Derivatives as Monoamine Oxidase Inhibitors
por: Reyes-Parada, Miguel, et al.
Publicado: (2020)

Parameters for Irreversible Inactivation of Monoamine Oxidase
por: Ramsay, Rona R., et al.
Publicado: (2020)

Coumarin-Based Dual Inhibitors of Human Carbonic Anhydrases and Monoamine Oxidases Featuring Amino Acyl and (Pseudo)-Dipeptidyl Appendages: In Vitro and Computational Studies
por: Agamennone, Mariangela, et al.
Publicado: (2022)

A twenty-year journey exploring coumarin-based derivatives as bioactive molecules
por: Pisani, Leonardo, et al.
Publicado: (2022)

3-Coumaranone derivatives as inhibitors of monoamine oxidase
por: Van Dyk, Adriaan S, et al.
Publicado: (2015)

Monoamine Oxidase B in Renal Cell Carcinoma
por: Hodorová, Ingrid, et al.
Publicado: (2018)

Cardiac monoamine oxidases: at the heart of mitochondrial dysfunction
por: Mialet-Perez, Jeanne, et al.
Publicado: (2020)

Monoamine Oxidase Inhibitors Prevent Glucose-Dependent Energy Production, Proliferation and Migration of Bladder Carcinoma Cells
por: Resta, Jessica, et al.
Publicado: (2022)

Evaluation of the Isoflavone Genistein as Reversible Human Monoamine Oxidase-A and -B Inhibitor
por: Zarmouh, Najla O., et al.
Publicado: (2016)

Monoamine Oxidase A Hypomethylation in Obsessive-Compulsive Disorder: Reversibility By Successful Psychotherapy?
por: Schiele, Miriam A, et al.
Publicado: (2020)

Associations of monoamine oxidase A gene first exon methylation with sexual abuse and current depression in women
por: Checknita, David, et al.
Publicado: (2018)

Design, Synthesis and Bioactivity Evaluation of Coumarin–BMT Hybrids as New Acetylcholinesterase Inhibitors
por: Zeng, Fanxin, et al.
Publicado: (2022)

Anti-Alzheimer activity of new coumarin-based derivatives targeting acetylcholinesterase inhibition
por: Kamel, Nahla N., et al.
Publicado: (2023)

3-Aryl-1-phenyl-1H-pyrazole derivatives as new multitarget directed ligands for the treatment of Alzheimer's disease, with acetylcholinesterase and monoamine oxidase inhibitory properties
por: Kumar, Ashwani, et al.
Publicado: (2013)

Mutual Information Rate and Bounds for It
por: Baptista, Murilo S., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_k7glinu9apitp4om998sua6ivc