TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss

TMEM106B, a type II lysosomal transmembrane protein, has recently been associated with brain aging, hypomyelinating leukodystrophy, frontotemporal lobar degeneration (FTLD) and several other brain disorders. TMEM106B is critical for proper lysosomal function and TMEM106B deficiency leads to myelinat...

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Detalles Bibliográficos
Autores principales: Feng, Tuancheng, Luan, Lin, Katz, Isabel Iscol, Ullah, Mohammed, Van Deerlin, Vivianna M., Trojanowski, John Q., Lee, Edward B., Hu, Fenghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919601/
https://www.ncbi.nlm.nih.gov/pubmed/35287730
http://dx.doi.org/10.1186/s40478-022-01334-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919601/
https://www.ncbi.nlm.nih.gov/pubmed/35287730
http://dx.doi.org/10.1186/s40478-022-01334-7

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