Macropinocytosis is an alternative pathway of cysteine acquisition and mitigates sorafenib-induced ferroptosis in hepatocellular carcinoma

BACKGROUND: Macropinocytosis, an important nutrient-scavenging pathway in certain cancer cells, allows cells to compensate for intracellular amino acid deficiency under nutrient-poor conditions. Ferroptosis caused by cysteine depletion plays a pivotal role in sorafenib responses during hepatocellula...

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Detalles Bibliográficos
Autores principales: Byun, Jun-Kyu, Lee, Seunghyeong, Kang, Gil Won, Lee, Yu Rim, Park, Soo Young, Song, Im-Sook, Yun, Jae Won, Lee, Jaebon, Choi, Yeon-Kyung, Park, Keun-Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919615/
https://www.ncbi.nlm.nih.gov/pubmed/35287706
http://dx.doi.org/10.1186/s13046-022-02296-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919615/
https://www.ncbi.nlm.nih.gov/pubmed/35287706
http://dx.doi.org/10.1186/s13046-022-02296-3

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