Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A4

Heterologous expression systems are important for analyzing the effects of genetic factors including single nucleotide polymorphisms on the functions of drug-metabolizing enzymes. In this study, we focused on a baculovirus-mammalian cell (Bac-Mam) expression system as a safer and more efficient appr...

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Detalles Bibliográficos
Autores principales: Miyauchi, Yuu, Kimura, Akane, Sawai, Madoka, Fujimoto, Keiko, Hirota, Yuko, Tanaka, Yoshitaka, Takechi, Shinji, Mackenzie, Peter I., Ishii, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919721/
https://www.ncbi.nlm.nih.gov/pubmed/35295333
http://dx.doi.org/10.3389/fphar.2022.832931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919721/
https://www.ncbi.nlm.nih.gov/pubmed/35295333
http://dx.doi.org/10.3389/fphar.2022.832931

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