Novel Small-Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics

Current heart failure therapies unload the failing heart without targeting the underlying problem of reduced cardiac contractility. Traditional inotropes (ie, calcitropes) stimulate contractility via energetically costly augmentation of calcium cycling and worsen patient survival. A new class of age...

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Detalles Bibliográficos
Autores principales: He, Huamei, Baka, Tomas, Balschi, James, Motani, Alykhan S., Nguyen, Kathy K., Liu, Qingxiang, Slater, Rebecca, Rock, Brooke, Wang, Chen, Hale, Christopher, Karamanlidis, Georgios, Hartman, James J., Malik, Fady I., Reagan, Jeff D., Luptak, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920024/
https://www.ncbi.nlm.nih.gov/pubmed/34743528
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.121.009195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920024/
https://www.ncbi.nlm.nih.gov/pubmed/34743528
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.121.009195

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