In silico high throughput mutagenesis and screening of signal peptides to mitigate N-terminal heterogeneity of recombinant monoclonal antibodies

N-terminal heterogeneity resulting from non-uniform signal peptide (SP) cleavage can potentially affect biologics property attributes and result in extended product development timelines. Few studies are available on engineering SPs systematically to address miscleavage issues. Herein, we developed...

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Detalles Bibliográficos
Autores principales: Yu, Xin, Conyne, Merlinda, Lake, Marc R., Walter, Karl A., Min, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920188/
https://www.ncbi.nlm.nih.gov/pubmed/35275041
http://dx.doi.org/10.1080/19420862.2022.2044977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920188/
https://www.ncbi.nlm.nih.gov/pubmed/35275041
http://dx.doi.org/10.1080/19420862.2022.2044977

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