Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants

SARS-CoV-2 Spike (Spike) binds to human angiotensin-converting enzyme 2 (ACE2) and the strength of this interaction could influence parameters relating to virulence. To explore whether population variants in ACE2 influence Spike binding and hence infection, we selected 10 ACE2 variants based on affi...

Descripción completa

Detalles Bibliográficos
Autores principales: MacGowan, Stuart A., Barton, Michael I., Kutuzov, Mikhail, Dushek, Omer, van der Merwe, P. Anton, Barton, Geoffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920257/
https://www.ncbi.nlm.nih.gov/pubmed/35235558
http://dx.doi.org/10.1371/journal.pcbi.1009922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920257/
https://www.ncbi.nlm.nih.gov/pubmed/35235558
http://dx.doi.org/10.1371/journal.pcbi.1009922

Ejemplares similares