p21 restricts influenza A virus by perturbing the viral polymerase complex and upregulating type I interferon signaling

Many cellular genes and networks induced in human lung epithelial cells infected with the influenza virus remain uncharacterized. Here, we find that p21 levels are elevated in response to influenza A virus (IAV) infection, which is independent of p53. Silencing, pharmacological inhibition or deletio...

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Detalles Bibliográficos
Autores principales: Ma, Chao, Li, Yuhan, Zong, Yanan, Velkov, Tony, Wang, Chenxi, Yang, Xinyu, Zhang, Ming, Jiang, Zhimin, Sun, Haoran, Tong, Qi, Sun, Honglei, Pu, Juan, Iqbal, Munir, Liu, Jinhua, Dai, Chongshan, Sun, Yipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920271/
https://www.ncbi.nlm.nih.gov/pubmed/35180274
http://dx.doi.org/10.1371/journal.ppat.1010295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920271/
https://www.ncbi.nlm.nih.gov/pubmed/35180274
http://dx.doi.org/10.1371/journal.ppat.1010295

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