Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions

Genetic variants at the SORT1 locus in humans, which cause increased SORT1 expression in the liver, are significantly associated with reduced plasma levels of LDL cholesterol and apolipoprotein B (apoB). However, the role of hepatic sortilin remains controversial, as genetic deletion of sortilin in...

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Detalles Bibliográficos
Autores principales: Conlon, Donna M., Schneider, Carolin V., Ko, Yi-An, Rodrigues, Amrith, Guo, Kathy, Hand, Nicholas J., Rader, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920325/
https://www.ncbi.nlm.nih.gov/pubmed/35113816
http://dx.doi.org/10.1172/JCI144334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920325/
https://www.ncbi.nlm.nih.gov/pubmed/35113816
http://dx.doi.org/10.1172/JCI144334

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