High-dose rifampin improves bactericidal activity without increased intracerebral inflammation in animal models of tuberculous meningitis

Tuberculous meningitis (TB meningitis) is the most severe form of tuberculosis (TB), requiring 12 months of multidrug treatment for cure, and is associated with high morbidity and mortality. High-dose rifampin (35 mg/kg/d) is safe and improves the bactericidal activity of the standard-dose (10 mg/kg...

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Detalles Bibliográficos
Autores principales: Ruiz-Bedoya, Camilo A., Mota, Filipa, Tucker, Elizabeth W., Mahmud, Farina J., Reyes-Mantilla, Maria I., Erice, Clara, Bahr, Melissa, Flavahan, Kelly, de Jesus, Patricia, Kim, John, Foss, Catherine A., Peloquin, Charles A., Hammoud, Dima A., Ordonez, Alvaro A., Pardo, Carlos A., Jain, Sanjay K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920328/
https://www.ncbi.nlm.nih.gov/pubmed/35085105
http://dx.doi.org/10.1172/JCI155851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920328/
https://www.ncbi.nlm.nih.gov/pubmed/35085105
http://dx.doi.org/10.1172/JCI155851

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