YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload

The heart utilizes multiple adaptive mechanisms to maintain pump function. Compensatory cardiac hypertrophy reduces wall stress and oxygen consumption, thereby protecting the heart against acute blood pressure elevation. The nuclear effector of the Hippo pathway, Yes-associated protein 1 (YAP), is a...

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Detalles Bibliográficos
Autores principales: Kashihara, Toshihide, Mukai, Risa, Oka, Shin-ichi, Zhai, Peiyong, Nakada, Yasuki, Yang, Zhi, Mizushima, Wataru, Nakahara, Tsutomu, Warren, Junco S., Abdellatif, Maha, Sadoshima, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920343/
https://www.ncbi.nlm.nih.gov/pubmed/35133975
http://dx.doi.org/10.1172/JCI150595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920343/
https://www.ncbi.nlm.nih.gov/pubmed/35133975
http://dx.doi.org/10.1172/JCI150595

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