Loss of legumain induces premature senescence and mediates aging‐related renal fibrosis

Aging is an independent risk factor for acute kidney injury and subsequent chronic kidney diseases, while the underlying mechanism is still elusive. Here, we found that renal tubules highly express a conserved lysosomal endopeptidase, legumain, which is significantly downregulated with the growing o...

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Detalles Bibliográficos
Autores principales: Wang, Dekun, Kang, Lichun, Chen, Chuan'ai, Guo, Jiasen, Du, Lingfang, Zhou, Donghui, Li, Gang, Zhang, Yuying, Mi, Xue, Zhang, Mianzhi, Liu, Shuxia, Tan, Xiaoyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920435/
https://www.ncbi.nlm.nih.gov/pubmed/35195326
http://dx.doi.org/10.1111/acel.13574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920435/
https://www.ncbi.nlm.nih.gov/pubmed/35195326
http://dx.doi.org/10.1111/acel.13574

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