Loss of heterochromatin and retrotransposon silencing as determinants in oocyte aging

Mammalian oocyte quality reduces with age. We show that prior to the occurrence of significant aneuploidy (9M in mouse), heterochromatin histone marks are lost, and oocyte maturation is impaired. This loss occurs in both constitutive and facultative heterochromatin marks but not in euchromatic activ...

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Detalles Bibliográficos
Autores principales: Wasserzug‐Pash, Peera, Rothman, Rachel, Reich, Eli, Zecharyahu, Lital, Schonberger, Oshrat, Weiss, Yifat, Srebnik, Naama, Cohen‐Hadad, Yaara, Weintraub, Amir, Ben‐Ami, Ido, Holzer, Hananel, Klutstein, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920445/
https://www.ncbi.nlm.nih.gov/pubmed/35166017
http://dx.doi.org/10.1111/acel.13568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920445/
https://www.ncbi.nlm.nih.gov/pubmed/35166017
http://dx.doi.org/10.1111/acel.13568

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