Metformin induces S‐adenosylmethionine restriction to extend the Caenorhabditis elegans healthspan through H3K4me3 modifiers

Metformin, a widely prescribed first‐line drug for the treatment of type II diabetes mellitus, has been shown to extend lifespan and delay the onset of age‐related diseases. The precisely mechanisms by which these effects are realized remain elusive. We find that metformin exposure is restricted to...

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Detalles Bibliográficos
Autores principales: Xiao, Yi, Liu, Fang, Kong, Qinghong, Zhu, Xinting, Wang, Haijuan, Li, Sanhua, Jiang, Nian, Yu, Changyan, Yun, Liu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920454/
https://www.ncbi.nlm.nih.gov/pubmed/35146893
http://dx.doi.org/10.1111/acel.13567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920454/
https://www.ncbi.nlm.nih.gov/pubmed/35146893
http://dx.doi.org/10.1111/acel.13567

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