Discovery of diminazene as a dual inhibitor of SARS-CoV-2 human host proteases TMPRSS2 and furin using cell-based assays

The proteases TMPRSS2 (transmembrane protease serine 2) and furin are known to play important roles in viral infectivity including systematic COVID-19 infection through priming of the spike protein of SARS-CoV-2 and related viruses. To discover small-molecules capable of inhibiting these host protea...

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Detalles Bibliográficos
Autores principales: Xu, Ya-Ming, Inacio, Marielle Cascaes, Liu, Manping X., Gunatilaka, A.A. Leslie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920474/
https://www.ncbi.nlm.nih.gov/pubmed/35815069
http://dx.doi.org/10.1016/j.crchbi.2022.100023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920474/
https://www.ncbi.nlm.nih.gov/pubmed/35815069
http://dx.doi.org/10.1016/j.crchbi.2022.100023

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