Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect

Alloreactive donor T cells undergo extensive metabolic reprogramming to become activated and induce graft-versus-host disease (GVHD) upon alloantigen encounter. It is generally thought that glycolysis, which promotes T cell growth and clonal expansion, is employed in this process. However, conflicti...

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Detalles Bibliográficos
Autores principales: Huang, Ying, Zou, Yujing, Jiao, Yiqun, Shi, Peijie, Nie, Xiaoli, Huang, Wei, Xiong, Chuanfeng, Choi, Michael, Huang, Charles, Macintyre, Andrew N., Nichols, Amanda, Li, Fang, Li, Chuan-Yuan, MacIver, Nancie J., Cardona, Diana M., Brennan, Todd V., Li, Zhiguo, Chao, Nelson J., Rathmell, Jeffrey C., Chen, Benny J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920494/
https://www.ncbi.nlm.nih.gov/pubmed/35296079
http://dx.doi.org/10.3389/fimmu.2022.751296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920494/
https://www.ncbi.nlm.nih.gov/pubmed/35296079
http://dx.doi.org/10.3389/fimmu.2022.751296

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