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Potential mechanisms of osteoprotegerin-induced damage to osteoclast adhesion structures via P2X7R-mediated MAPK signaling

Osteoprotegerin (OPG) is a negative regulator of osteoclast formation by competing with receptor activator of the nuclear factor-κB (NF-κB) ligand (RANKL) for RANK. OPG is not only a soluble decoy receptor for RANKL, but is also considered as a direct effector of osteoclast functions. However, the m...

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Detalles Bibliográficos
Autores principales: Ma, Yonggang, Shi, Xueni, Zhao, Hongyan, Song, Ruilong, Zou, Hui, Zhu, Jiaqiao, Liu, Zongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920495/
https://www.ncbi.nlm.nih.gov/pubmed/35266010
http://dx.doi.org/10.3892/ijmm.2022.5115