Activation of the CaMKII-Sarm1-ASK1-p38 MAP kinase pathway protects against axon degeneration caused by loss of mitochondria

Mitochondrial defects are tightly linked to axon degeneration, yet the underlying cellular mechanisms remain poorly understood. In Caenorhabditis elegans, PVQ axons that lack mitochondria degenerate spontaneously with age. Using an unbiased genetic screen, we found that cell-specific activation of C...

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Detalles Bibliográficos
Autores principales: Ding, Chen, Wu, Youjun, Dabas, Hadas, Hammarlund, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920508/
https://www.ncbi.nlm.nih.gov/pubmed/35285800
http://dx.doi.org/10.7554/eLife.73557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920508/
https://www.ncbi.nlm.nih.gov/pubmed/35285800
http://dx.doi.org/10.7554/eLife.73557

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