How Sequence Context-Dependent Mutability Drives Mutation Rate Variation in the Genome

The rate of mutations varies >100-fold across the genome, altering the rate of evolution, and susceptibility to genetic diseases. The strongest predictor of mutation rate is the sequence itself, varying 75-fold between trinucleotides. The fact that DNA sequence drives its own mutation rate raises...

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Detalles Bibliográficos
Autores principales: Oman, Madeleine, Alam, Aqsa, Ness, Rob W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920511/
https://www.ncbi.nlm.nih.gov/pubmed/35218359
http://dx.doi.org/10.1093/gbe/evac032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920511/
https://www.ncbi.nlm.nih.gov/pubmed/35218359
http://dx.doi.org/10.1093/gbe/evac032

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