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How Sequence Context-Dependent Mutability Drives Mutation Rate Variation in the Genome
The rate of mutations varies >100-fold across the genome, altering the rate of evolution, and susceptibility to genetic diseases. The strongest predictor of mutation rate is the sequence itself, varying 75-fold between trinucleotides. The fact that DNA sequence drives its own mutation rate raises...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920511/ https://www.ncbi.nlm.nih.gov/pubmed/35218359 http://dx.doi.org/10.1093/gbe/evac032 |