Cargando…

Folate Receptor-Alpha Targeted 7x19 CAR-γδT Suppressed Triple-Negative Breast Cancer Xenograft Model in Mice

BACKGROUND: Triple-negative breast cancer (TNBC) is the worst prognosis subtype of breast cancer due to lack of specific targets. Recent studies have shown that immunotherapy may solve that problem by targeting folate receptor-alpha (FRα). METHODS: Gene modified γδ T cells were manufactured to expre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ye, Xueshuai, Deng, Xinna, Wen, Junye, Li, Yang, Zhang, Mengya, Cai, Ziqi, Liu, Guan, Wang, Hezhi, Cai, Jianhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8920629/ https://www.ncbi.nlm.nih.gov/pubmed/35295709 http://dx.doi.org/10.1155/2022/2112898

Ejemplares similares

Minicircle DNA-Mediated CAR T Cells Targeting CD44 Suppressed Hepatocellular Carcinoma Both in vitro and in vivo
por: Wang, Hezhi, et al.
Publicado: (2020)

Anti-HER2 scFv-CCL19-IL7 recombinant protein inhibited gastric tumor growth in vivo
por: Zhang, Haiqiang, et al.
Publicado: (2022)

Nonviral mcDNA-mediated bispecific CAR T cells kill tumor cells in an experimental mouse model of hepatocellular carcinoma
por: Wang, Hezhi, et al.
Publicado: (2022)

Effective adoptive immunotherapy of triple-negative breast cancer by folate receptor-alpha redirected CAR T cells is influenced by surface antigen expression level
por: Song, De-Gang, et al.
Publicado: (2016)

Clinicopathological Correlates of γδ T Cell Infiltration in Triple-Negative Breast Cancer
por: Boissière-Michot, Florence, et al.
Publicado: (2021)

Folate receptor alpha expression associates with improved disease-free survival in triple negative breast cancer patients
por: Norton, Nadine, et al.
Publicado: (2020)

Metabolic Response of Triple-Negative Breast Cancer to Folate Restriction
por: Coleman, Michael F., et al.
Publicado: (2021)

Histological Analysis of γδ T Lymphocytes Infiltrating Human Triple-Negative Breast Carcinomas
por: Hidalgo, Jose Villacorta, et al.
Publicado: (2014)

Folate receptor alpha (FRA) expression in breast cancer: identification of a new molecular subtype and association with triple negative disease
por: O’Shannessy, Daniel J, et al.
Publicado: (2012)

Folate Receptor-α (FOLR1) Expression and Function in Triple Negative Tumors
por: Necela, Brian M., et al.
Publicado: (2015)

ImmunoPET Imaging Identifies the Optimal Timepoint for Combination Therapy in Xenograft Models of Triple-Negative Breast Cancer
por: Li, Ziqi, et al.
Publicado: (2023)

Identification of a peptide for folate receptor alpha by phage display and its tumor targeting activity in ovary cancer xenograft
por: Xing, Lijun, et al.
Publicado: (2018)

Correction: Folate Receptor-α (FOLR1) Expression and Function in Triple Negative Tumors
por: Necela, Brian M., et al.
Publicado: (2015)

Folate-Functionalized DNA Origami for Targeted Delivery of Doxorubicin to Triple-Negative Breast Cancer
por: Pal, Suchetan, et al.
Publicado: (2021)

Predictors of success in establishing orthotopic patient-derived xenograft models of triple negative breast cancer
por: Echeverria, Gloria V., et al.
Publicado: (2023)

Folate-Functionalization Enhances Cytotoxicity of Multivalent DNA Nanocages on Triple-Negative Breast Cancer Cells
por: Unida, Valeria, et al.
Publicado: (2022)

Brain Uptake of Folate Forms in the Presence of Folate Receptor Alpha Antibodies in Young Rats: Folate and Antibody Distribution
por: Bobrowski-Khoury, Natasha, et al.
Publicado: (2023)

Pharmacologic profiling of patient-derived xenograft models of primary treatment-naïve triple-negative breast cancer
por: Powell, Reid T., et al.
Publicado: (2020)

CAR-T cell therapy in triple-negative breast cancer: Hunting the invisible devil
por: Nasiri, Fatemeh, et al.
Publicado: (2022)

γδ-Enriched CAR-T cell therapy for bone metastatic castrate-resistant prostate cancer
por: Frieling, Jeremy S., et al.
Publicado: (2023)

Metabolic consequences of HIF silencing in a triple negative human breast cancer xenograft
por: Bharti, Santosh K., et al.
Publicado: (2018)

Activity of docetaxel, carboplatin, and doxorubicin in patient-derived triple-negative breast cancer xenografts
por: Martin, Miguel, et al.
Publicado: (2021)

Targeting folate receptor alpha for cancer treatment
por: Cheung, Anthony, et al.
Publicado: (2016)

Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer
por: Hutchinson, Samantha A., et al.
Publicado: (2021)

BiTE‐Secreting CAR‐γδT as a Dual Targeting Strategy for the Treatment of Solid Tumors
por: Huang, Shi‐Wei, et al.
Publicado: (2023)

Individual xenograft as a personalized therapeutic resort for women with metastatic triple-negative breast carcinoma
por: Bousquet, Guilhem, et al.
Publicado: (2014)

Yiqi Formula Enhances the Antitumor Effects of Erlotinib for Treatment of Triple-Negative Breast Cancer Xenografts
por: Liao, Ming-juan, et al.
Publicado: (2014)

Molecular Investigation on a Triple Negative Breast Cancer Xenograft Model Exposed to Proton Beams
por: Cammarata, Francesco P., et al.
Publicado: (2020)

Edelfosine nanoemulsions inhibit tumor growth of triple negative breast cancer in zebrafish xenograft model
por: Saraiva, Sofia M., et al.
Publicado: (2021)

Identification of two cancer stem cell-like populations in triple-negative breast cancer xenografts
por: Nakayama, Jun, et al.
Publicado: (2022)

Expression status of folate receptor alpha is a predictor of survival in pancreatic ductal adenocarcinoma
por: Cai, Lei, et al.
Publicado: (2017)

Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor
por: Pan, Hong, et al.
Publicado: (2020)

Endocytosis of GPI-linked membrane folate receptor-alpha
Publicado: (1996)

Intercellular Adhesion Molecule-1 as Target for CAR-T-Cell Therapy of Triple-Negative Breast Cancer
por: Wei, Heng, et al.
Publicado: (2020)

Functional and genomic characterisation of a xenograft model system for the study of metastasis in triple-negative breast cancer
por: Johnstone, Cameron N., et al.
Publicado: (2018)

Drug resistance profiling of a new triple negative breast cancer patient-derived xenograft model
por: Matossian, Margarite D., et al.
Publicado: (2019)

Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer
por: Merino, D., et al.
Publicado: (2019)

Establishment of chemosensitivity tests in triple-negative and BRCA-mutated breast cancer patient-derived xenograft models
por: Park, Hyung Seok, et al.
Publicado: (2019)

Immunologically “cold” triple negative breast cancers engraft at a higher rate in patient derived xenografts
por: Petrosyan, Varduhi, et al.
Publicado: (2022)

Folate Receptor Targeted Alpha-Therapy Using Terbium-149
por: Müller, Cristina, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_4qnqirm4o92m48uu7umft7silh