DNA methylation–independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins

The programmable CRISPR/Cas9 DNA nuclease is a versatile genome editing tool, but it requires the host cell DNA repair machinery to alter genomic sequences. This fact leads to unpredictable changes of the genome at the cut sites. Genome editing tools that can alter the genome without causing DNA dou...

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Detalles Bibliográficos
Autores principales: Ding, Li, Schmitt, Lukas Theo, Brux, Melanie, Sürün, Duran, Augsburg, Martina, Lansing, Felix, Mircetic, Jovan, Theis, Mirko, Buchholz, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921183/
https://www.ncbi.nlm.nih.gov/pubmed/35288457
http://dx.doi.org/10.26508/lsa.202101321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921183/
https://www.ncbi.nlm.nih.gov/pubmed/35288457
http://dx.doi.org/10.26508/lsa.202101321

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