Inhibition of mitochondrial LonP1 protease by allosteric blockade of ATP binding and hydrolysis via CDDO and its derivatives

The mitochondrial protein LonP1 is an ATP-dependent protease that mitigates cell stress and calibrates mitochondrial metabolism and energetics. Biallelic mutations in the LONP1 gene are known to cause a broad spectrum of diseases, and LonP1 dysregulation is also implicated in cancer and age-related...

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Detalles Bibliográficos
Autores principales: Lee, Jae, Pandey, Ashutosh K., Venkatesh, Sundararajan, Thilagavathi, Jayapalraja, Honda, Tadashi, Singh, Kamal, Suzuki, Carolyn K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921294/
https://www.ncbi.nlm.nih.gov/pubmed/35151690
http://dx.doi.org/10.1016/j.jbc.2022.101719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921294/
https://www.ncbi.nlm.nih.gov/pubmed/35151690
http://dx.doi.org/10.1016/j.jbc.2022.101719

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