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Poly(rC)-binding protein 1 represses ferritinophagy-mediated ferroptosis in head and neck cancer

A cytosolic iron chaperone poly(rC)-binding protein 1 (PCBP1) is a multifunctional RNA-binding protein involving gene transcription, RNA regulation, and iron loading to ferritins. PCBP1 is also known to repress autophagy, but the role of PCBP1 in ferritinophagy and ferroptosis remains unrevealed. Th...

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Detalles Bibliográficos
Autores principales: Lee, Jaewang, You, Ji Hyeon, Roh, Jong-Lyel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921323/
https://www.ncbi.nlm.nih.gov/pubmed/35290903
http://dx.doi.org/10.1016/j.redox.2022.102276