Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis

Roundabout 4 (Robo4) is a transmembrane receptor that expresses specifically in endothelial cells. Soluble Robo4 was reported in the human plasma and mouse serum and is inhibitory towards FGF- and VEGF-induced angiogenesis. It remains unknown how soluble Robo4 is generated and if soluble Robo4 regul...

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Detalles Bibliográficos
Autores principales: Xiao, Wenyuan, Pinilla-Baquero, Alejandro, Faulkner, John, Song, Xuehong, Prabhakar, Pradeep, Qiu, Hong, Moremen, Kelley W., Ludwig, Andreas, Dempsey, Peter J., Azadi, Parastoo, Wang, Lianchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921330/
https://www.ncbi.nlm.nih.gov/pubmed/35288626
http://dx.doi.org/10.1038/s41598-022-08227-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921330/
https://www.ncbi.nlm.nih.gov/pubmed/35288626
http://dx.doi.org/10.1038/s41598-022-08227-8

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