Single serine on TSC2 exerts biased control over mTORC1 activation mediated by ERK1/2 but not Akt

Tuberous sclerosis complex-2 (TSC2) negatively regulates mammalian target of rapamycin complex 1 (mTORC1), and its activity is reduced by protein kinase B (Akt) and extracellular response kinase (ERK1/2) phosphorylation to activate mTORC1. Serine 1364 (human) on TSC2 bidirectionally modifies mTORC1...

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Detalles Bibliográficos
Autores principales: Dunkerly-Eyring, Brittany L, Pan, Shi, Pinilla-Vera, Miguel, McKoy, Desirae, Mishra, Sumita, Grajeda Martinez, Maria I, Oeing, Christian U, Ranek, Mark J, Kass, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921838/
https://www.ncbi.nlm.nih.gov/pubmed/35288456
http://dx.doi.org/10.26508/lsa.202101169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921838/
https://www.ncbi.nlm.nih.gov/pubmed/35288456
http://dx.doi.org/10.26508/lsa.202101169

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