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Two-Metal-Ion Catalysis: Inhibition of DNA Polymerase Activity by a Third Divalent Metal Ion
Almost all DNA polymerases (pols) exhibit bell-shaped activity curves as a function of both pH and Mg(2+) concentration. The pol activity is reduced when the pH deviates from the optimal value. When the pH is too low the concentration of a deprotonated general base (namely, the attacking 3′-hydroxyl...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921852/ https://www.ncbi.nlm.nih.gov/pubmed/35300112 http://dx.doi.org/10.3389/fmolb.2022.824794 |