Localization of Nerve Growth Factor Expression to Structurally Damaged Cartilaginous Tissues in Human Lumbar Facet Joint Osteoarthritis

PURPOSE: Nerve Growth Factor (NGF) is a pivotal mediator of chronic pain and plays a role in bone remodelling. Through its high affinity receptor TrkA, NGF induces substance P (SP) as key downstream mediator of pain and local inflammation. Here we analysed NGF, TrkA and SP tissue distribution in fac...

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Detalles Bibliográficos
Autores principales: Seidel, Matthias F., Netzer, Cordula, Chobaz, Véronique, Hügle, Thomas, Geurts, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921992/
https://www.ncbi.nlm.nih.gov/pubmed/35300334
http://dx.doi.org/10.3389/fimmu.2022.783076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921992/
https://www.ncbi.nlm.nih.gov/pubmed/35300334
http://dx.doi.org/10.3389/fimmu.2022.783076

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