Apolipoprotein E Isoform-Dependent Effects on Human Amyloid Precursor Protein/Aβ-Induced Behavioral Alterations and Cognitive Impairments and Insoluble Cortical Aβ42 Levels

Mice expressing human amyloid precursor protein (APP) containing the dominant Swedish and Iberian mutations (App(NL–F)) or also Arctic mutation (App(NL–G–F)) show neuropathology and hippocampus-dependent cognitive impairments pertinent to Alzheimer’s disease (AD) in mouse models at 18 and 6 months o...

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Detalles Bibliográficos
Autores principales: Holden, Sarah, Kundu, Payel, Torres, Eileen R. S., Sudhakar, Reetesh, Krenik, Destine, Grygoryev, Dmytro, Turker, Mitchel S., Raber, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922030/
https://www.ncbi.nlm.nih.gov/pubmed/35299942
http://dx.doi.org/10.3389/fnagi.2022.767558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922030/
https://www.ncbi.nlm.nih.gov/pubmed/35299942
http://dx.doi.org/10.3389/fnagi.2022.767558

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