CCL5 Suppresses Klotho Expression via p-STAT3/DNA Methyltransferase1-Mediated Promoter Hypermethylation

BACKGROUND: Enhanced inflammation and reduced Klotho are common features in chronic kidney disease (CKD). Inflammation induces DNA hypermethylation. This study assessed the performance of inflammatory marker C-C motif chemokine 5 (CCL5) in epigenetic regulation of Klotho expression. METHODS: Fifty C...

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Detalles Bibliográficos
Autores principales: Liu, QiFeng, Li, ShaSha, Yu, LiXia, Yin, XiaoYa, Liu, Xi, Ye, JianMing, Lu, GuoYuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922032/
https://www.ncbi.nlm.nih.gov/pubmed/35299661
http://dx.doi.org/10.3389/fphys.2022.856088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922032/
https://www.ncbi.nlm.nih.gov/pubmed/35299661
http://dx.doi.org/10.3389/fphys.2022.856088

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