RNA sensing via the RIG‐I‐like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency

RNA editing by the adenosine deaminase ADAR1 prevents innate immune responses to endogenous RNAs. In ADAR1‐deficient cells, unedited self RNAs form base‐paired structures that resemble viral RNAs and inadvertently activate the cytosolic RIG‐I‐like receptor (RLR) MDA5, leading to an antiviral type I...

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Detalles Bibliográficos
Autores principales: Stok, Jorn E, Oosenbrug, Timo, ter Haar, Laurens R, Gravekamp, Dennis, Bromley, Christian P, Zelenay, Santiago, Reis e Sousa, Caetano, van der Veen, Annemarthe G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922249/
https://www.ncbi.nlm.nih.gov/pubmed/35156720
http://dx.doi.org/10.15252/embj.2021109760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922249/
https://www.ncbi.nlm.nih.gov/pubmed/35156720
http://dx.doi.org/10.15252/embj.2021109760

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