Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity

Cellular senescence is a state of stable growth arrest and a desired outcome of tumor suppressive interventions. Treatment with many anti‐cancer drugs can cause premature senescence of non‐malignant cells. These therapy‐induced senescent cells can have pro‐tumorigenic and pro‐disease functions via a...

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Detalles Bibliográficos
Autores principales: Wang, Boshi, Varela‐Eirin, Marta, Brandenburg, Simone M, Hernandez‐Segura, Alejandra, van Vliet, Thijmen, Jongbloed, Elisabeth M, Wilting, Saskia M, Ohtani, Naoko, Jager, Agnes, Demaria, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922251/
https://www.ncbi.nlm.nih.gov/pubmed/34985783
http://dx.doi.org/10.15252/embj.2021108946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922251/
https://www.ncbi.nlm.nih.gov/pubmed/34985783
http://dx.doi.org/10.15252/embj.2021108946

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