Cargando…

Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity

Cellular senescence is a state of stable growth arrest and a desired outcome of tumor suppressive interventions. Treatment with many anti‐cancer drugs can cause premature senescence of non‐malignant cells. These therapy‐induced senescent cells can have pro‐tumorigenic and pro‐disease functions via a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Boshi, Varela‐Eirin, Marta, Brandenburg, Simone M, Hernandez‐Segura, Alejandra, van Vliet, Thijmen, Jongbloed, Elisabeth M, Wilting, Saskia M, Ohtani, Naoko, Jager, Agnes, Demaria, Marco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922251/ https://www.ncbi.nlm.nih.gov/pubmed/34985783 http://dx.doi.org/10.15252/embj.2021108946

Ejemplares similares

The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon
por: Fontana, Luigi, et al.
Publicado: (2018)

Inhibiting CDK4/6 in Breast Cancer with Palbociclib, Ribociclib, and Abemaciclib: Similarities and Differences
por: Braal, C. Louwrens, et al.
Publicado: (2020)

Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche
por: Peng, Xiaohong, et al.
Publicado: (2020)

A Systematic Review of the Use of Circulating Cell-Free DNA Dynamics to Monitor Response to Treatment in Metastatic Breast Cancer Patients
por: Jongbloed, Elisabeth M., et al.
Publicado: (2021)

Senescence and cancer — role and therapeutic opportunities
por: Schmitt, Clemens A., et al.
Publicado: (2022)

Identification of stable senescence‐associated reference genes
por: Hernandez‐Segura, Alejandra, et al.
Publicado: (2019)

Cost-Effectiveness of Abemaciclib in Early Breast Cancer Patients: One Size Fits All or Tailoring to Patients’ Needs?
por: Jongbloed, Elisabeth M, et al.
Publicado: (2023)

Cellular senescence and the tumour microenvironment
por: Takasugi, Masaki, et al.
Publicado: (2022)

The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?
por: Ohtani, Naoko
Publicado: (2022)

Knockdown of CDK2AP1 in Primary Human Fibroblasts Induces p53 Dependent Senescence
por: Alsayegh, Khaled N., et al.
Publicado: (2015)

Impact of senescence‐associated secretory phenotype and its potential as a therapeutic target for senescence‐associated diseases
por: Watanabe, Sugiko, et al.
Publicado: (2017)

Integrative whole-genome and transcriptome analysis of HER2-amplified metastatic breast cancer
por: Verschoor, Noortje, et al.
Publicado: (2023)

CDK4/6 inhibitor: from quiescence to senescence
por: Yoshida, Akihiro, et al.
Publicado: (2015)

Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53
por: Maehara, Kayoko, et al.
Publicado: (2005)

Cdk6: At the interface of Rb and p53
por: Nebenfuehr, Sofie, et al.
Publicado: (2018)

p53 action in apoptosis and senescence
por: Lowe, SW, et al.
Publicado: (2000)

Irreversibility of cellular senescence: dual roles of p16(INK4a)/Rb-pathway in cell cycle control
por: Takahashi, Akiko, et al.
Publicado: (2007)

Combined CDK2 and CDK4/6 Inhibition Overcomes Palbociclib Resistance in Breast Cancer by Enhancing Senescence
por: Pandey, Kamal, et al.
Publicado: (2020)

MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation
por: Lena, A.M., et al.
Publicado: (2012)

CDK4 T172 Phosphorylation Is Central in a CDK7-Dependent Bidirectional CDK4/CDK2 Interplay Mediated by p21 Phosphorylation at the Restriction Point
por: Bisteau, Xavier, et al.
Publicado: (2013)

Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression
por: Kohli, Jaskaren, et al.
Publicado: (2022)

Cdk2: a key regulator of the senescence control function of Myc
por: Hydbring, Per, et al.
Publicado: (2010)

Senescence as a therapeutically relevant response to CDK4/6 inhibitors
por: Wagner, Verena, et al.
Publicado: (2020)

p53-induced autophagy and senescence
por: Sui, Xinbing, et al.
Publicado: (2015)

Residual Cdk1/2 activity after DNA damage promotes senescence
por: Müllers, Erik, et al.
Publicado: (2017)

Characterization of the p53 Response to Oncogene-Induced Senescence
por: Ruiz, Lidia, et al.
Publicado: (2008)

Cellular senescence: the good, the bad and the unknown
por: Huang, Weijun, et al.
Publicado: (2022)

Real-time in vivo imaging of p16(Ink4a )gene expression: a new approach to study senescence stress signaling in living animals
por: Ohtani, Naoko, et al.
Publicado: (2010)

Activation of CDK4 by Tax chemosensitizes p53-mutant cells to DNA damage
por: Semmes, O John, et al.
Publicado: (2014)

p53, ROS and senescence in the control of aging
por: Vigneron, Arnaud, et al.
Publicado: (2010)

Role of p53 in the Regulation of Cellular Senescence
por: Mijit, Mahmut, et al.
Publicado: (2020)

Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence
por: Brookes, Sharon, et al.
Publicado: (2015)

D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway
por: Xu, Xingxing, et al.
Publicado: (2020)

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity
por: Pogacar, Ziva, et al.
Publicado: (2022)

Cellular senescence in the response of HR(+) breast cancer to radiotherapy and CDK4/6 inhibitors
por: Klapp, Vanessa, et al.
Publicado: (2023)

Machine learning-based somatic variant calling in cell-free DNA of metastatic breast cancer patients using large NGS panels
por: Jongbloed, Elisabeth M., et al.
Publicado: (2023)

A tale on rabbit ears and pan-handles, the rings that rule all
por: Smid, Marcel, et al.
Publicado: (2019)

Molecular mechanism of G(1) arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells
por: Tao, Yan-Fang, et al.
Publicado: (2017)

CDK4 inhibition diminishes p53 activation by MDM2 antagonists
por: Sriraman, Anusha, et al.
Publicado: (2018)

The prognostic role of p53 and its correlation with CDK9 in urothelial carcinoma
por: Borowczak, Jędrzej, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_d0jmvnh8btb7m0cgv38frpo9su