A multitask GNN-based interpretable model for discovery of selective JAK inhibitors

The Janus kinase (JAK) family plays a pivotal role in most cytokine-mediated inflammatory and autoimmune responses via JAK/STAT signaling, and administration of JAK inhibitors is a promising therapeutic strategy for several diseases including COVID-19. However, to screen and design selective JAK inh...

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Detalles Bibliográficos
Autores principales: Wang, Yimeng, Gu, Yaxin, Lou, Chaofeng, Gong, Yuning, Wu, Zengrui, Li, Weihua, Tang, Yun, Liu, Guixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922399/
https://www.ncbi.nlm.nih.gov/pubmed/35292114
http://dx.doi.org/10.1186/s13321-022-00593-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922399/
https://www.ncbi.nlm.nih.gov/pubmed/35292114
http://dx.doi.org/10.1186/s13321-022-00593-9

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