Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus

• Tilorone dihydrochloride possesses robust anti-SFTSV activity in vitro and in vivo. • Intraperitoneal administration of tilorone leads to protection against intracranial lethal challenge of SFTSV. • The anti-SFTSV mechanism of tilorone is through stimulation of host innate immunity. • Pre-treatmen...

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Autores principales: Yang, Jingjing, Yan, Yunzheng, Dai, Qingsong, Yin, Jiye, Zhao, Lei, Li, Yuexiang, Li, Wei, Zhong, Wu, Cao, Ruiyuan, Li, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922426/
https://www.ncbi.nlm.nih.gov/pubmed/35234618
http://dx.doi.org/10.1016/j.virs.2022.01.014
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author Yang, Jingjing
Yan, Yunzheng
Dai, Qingsong
Yin, Jiye
Zhao, Lei
Li, Yuexiang
Li, Wei
Zhong, Wu
Cao, Ruiyuan
Li, Song
author_facet Yang, Jingjing
Yan, Yunzheng
Dai, Qingsong
Yin, Jiye
Zhao, Lei
Li, Yuexiang
Li, Wei
Zhong, Wu
Cao, Ruiyuan
Li, Song
author_sort Yang, Jingjing
collection PubMed
description • Tilorone dihydrochloride possesses robust anti-SFTSV activity in vitro and in vivo. • Intraperitoneal administration of tilorone leads to protection against intracranial lethal challenge of SFTSV. • The anti-SFTSV mechanism of tilorone is through stimulation of host innate immunity. • Pre-treatment with tilorone can prevent mice from lethal SFTSV challenge.
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spelling pubmed-89224262022-03-21 Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus Yang, Jingjing Yan, Yunzheng Dai, Qingsong Yin, Jiye Zhao, Lei Li, Yuexiang Li, Wei Zhong, Wu Cao, Ruiyuan Li, Song Virol Sin Letter • Tilorone dihydrochloride possesses robust anti-SFTSV activity in vitro and in vivo. • Intraperitoneal administration of tilorone leads to protection against intracranial lethal challenge of SFTSV. • The anti-SFTSV mechanism of tilorone is through stimulation of host innate immunity. • Pre-treatment with tilorone can prevent mice from lethal SFTSV challenge. Wuhan Institute of Virology, Chinese Academy of Sciences 2022-01-18 /pmc/articles/PMC8922426/ /pubmed/35234618 http://dx.doi.org/10.1016/j.virs.2022.01.014 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Letter
Yang, Jingjing
Yan, Yunzheng
Dai, Qingsong
Yin, Jiye
Zhao, Lei
Li, Yuexiang
Li, Wei
Zhong, Wu
Cao, Ruiyuan
Li, Song
Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus
title Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus
title_full Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus
title_fullStr Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus
title_full_unstemmed Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus
title_short Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus
title_sort tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922426/
https://www.ncbi.nlm.nih.gov/pubmed/35234618
http://dx.doi.org/10.1016/j.virs.2022.01.014
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