Peptide Model of the Mutant Proinsulin Syndrome. II. Nascent Structure and Biological Implications

Toxic misfolding of proinsulin variants in β-cells defines a monogenic diabetes syndrome, designated mutant INS-gene induced diabetes of the young (MIDY). In our first study (previous article in this issue), we described a one-disulfide peptide model of a proinsulin folding intermediate and its use...

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Detalles Bibliográficos
Autores principales: Yang, Yanwu, Glidden, Michael D., Dhayalan, Balamurugan, Zaykov, Alexander N., Chen, Yen-Shan, Wickramasinghe, Nalinda P., DiMarchi, Richard D., Weiss, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922542/
https://www.ncbi.nlm.nih.gov/pubmed/35299958
http://dx.doi.org/10.3389/fendo.2022.821091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922542/
https://www.ncbi.nlm.nih.gov/pubmed/35299958
http://dx.doi.org/10.3389/fendo.2022.821091

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