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Peptide Model of the Mutant Proinsulin Syndrome. II. Nascent Structure and Biological Implications
Toxic misfolding of proinsulin variants in β-cells defines a monogenic diabetes syndrome, designated mutant INS-gene induced diabetes of the young (MIDY). In our first study (previous article in this issue), we described a one-disulfide peptide model of a proinsulin folding intermediate and its use...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8922542/ https://www.ncbi.nlm.nih.gov/pubmed/35299958 http://dx.doi.org/10.3389/fendo.2022.821091 |