Novel mechanisms of action contributing to benralizumab's potent anti-eosinophilic activity

BACKGROUND: Benralizumab is a humanised, anti-interleukin-5 receptor α monoclonal antibody with anti-eosinophilic activity. Lack of fucose (afucosylation) increases its affinity to CD16a and significantly enhances antibody-dependent cell-mediated cytotoxicity by natural killer (NK) cells. Although b...

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Detalles Bibliográficos
Autores principales: Dagher, Rania, Kumar, Varsha, Copenhaver, Alan M., Gallagher, Sandra, Ghaedi, Mahboobe, Boyd, Jonathan, Newbold, Paul, Humbles, Alison A., Kolbeck, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923056/
https://www.ncbi.nlm.nih.gov/pubmed/34289975
http://dx.doi.org/10.1183/13993003.04306-2020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923056/
https://www.ncbi.nlm.nih.gov/pubmed/34289975
http://dx.doi.org/10.1183/13993003.04306-2020

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