Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators

[Image: see text] T-type voltage-gated Ca(2+) channels have been implicated in many human disorders, and there has been increasing interest in developing highly selective and potent T-type Ca(2+) channel modulators for potential clinical use. However, the unique biophysical properties of T-type Ca(2...

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Detalles Bibliográficos
Autores principales: Zhang, Yan-Ling, Moran, Sean P., Allen, Andrew, Baez-Nieto, David, Xu, Qihong, Wang, Lei A., Martenis, William E., Sacher, Joshua R., Gale, Jennifer P., Weïwer, Michel, Wagner, Florence F., Pan, Jen Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923061/
https://www.ncbi.nlm.nih.gov/pubmed/35311021
http://dx.doi.org/10.1021/acsptsci.1c00233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923061/
https://www.ncbi.nlm.nih.gov/pubmed/35311021
http://dx.doi.org/10.1021/acsptsci.1c00233

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