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Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators
[Image: see text] T-type voltage-gated Ca(2+) channels have been implicated in many human disorders, and there has been increasing interest in developing highly selective and potent T-type Ca(2+) channel modulators for potential clinical use. However, the unique biophysical properties of T-type Ca(2...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923061/ https://www.ncbi.nlm.nih.gov/pubmed/35311021 http://dx.doi.org/10.1021/acsptsci.1c00233 |