Analyses of HIV proteases variants at the threshold of viability reveals relationships between processing efficiency and fitness

Investigating the relationships between protein function and fitness provides keys for understanding biochemical mechanisms that underly evolution. Mutations with partial fitness defects can delineate the threshold of biochemical function required for viability. We utilized a previous deep mutationa...

Descripción completa

Detalles Bibliográficos
Autores principales: Schneider-Nachum, Gily, Flynn, Julia, Mavor, David, Schiffer, Celia A, Bolon, Daniel N A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923237/
https://www.ncbi.nlm.nih.gov/pubmed/35299788
http://dx.doi.org/10.1093/ve/veab103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923237/
https://www.ncbi.nlm.nih.gov/pubmed/35299788
http://dx.doi.org/10.1093/ve/veab103

Ejemplares similares