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Analyses of HIV proteases variants at the threshold of viability reveals relationships between processing efficiency and fitness
Investigating the relationships between protein function and fitness provides keys for understanding biochemical mechanisms that underly evolution. Mutations with partial fitness defects can delineate the threshold of biochemical function required for viability. We utilized a previous deep mutationa...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923237/ https://www.ncbi.nlm.nih.gov/pubmed/35299788 http://dx.doi.org/10.1093/ve/veab103 |