CTP sensing and Mec1(ATR)-Rad53(CHK1/CHK2) mediate a two-layered response to inhibition of glutamine metabolism

Glutamine analogs are potent suppressors of general glutamine metabolism with anti-cancer activity. 6-diazo-5-oxo-L-norleucine (DON) is an orally available glutamine analog which has been recently improved by structural modification for cancer treatment. Here, we explored the chemogenomic landscape...

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Detalles Bibliográficos
Autores principales: Ajazi, Arta, Choudhary, Ramveer, Tronci, Laura, Bachi, Angela, Bruhn, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923462/
https://www.ncbi.nlm.nih.gov/pubmed/35239666
http://dx.doi.org/10.1371/journal.pgen.1010101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8923462/
https://www.ncbi.nlm.nih.gov/pubmed/35239666
http://dx.doi.org/10.1371/journal.pgen.1010101

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