Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome

Transfer RNA-derived fragments (tRFs) are emerging small noncoding RNAs that, although commonly altered in cancer, have poorly defined roles in tumorigenesis(1). Here we show that pseudouridylation (Ψ) of a stem cell-enriched tRF subtype(2), mini tRFs containing a 5′ terminal oligoguanine (mTOG), se...

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Detalles Bibliográficos
Autores principales: Guzzi, Nicola, Muthukumar, Sowndarya, Cieśla, Maciej, Todisco, Gabriele, Ngoc, Phuong Cao Thi, Madej, Magdalena, Munita, Roberto, Fazio, Serena, Ekström, Simon, Mortera-Blanco, Teresa, Jansson, Monika, Nannya, Yasuhito, Cazzola, Mario, Ogawa, Seishi, Malcovati, Luca, Hellström-Lindberg, Eva, Dimitriou, Marios, Bellodi, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924001/
https://www.ncbi.nlm.nih.gov/pubmed/35292784
http://dx.doi.org/10.1038/s41556-022-00852-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924001/
https://www.ncbi.nlm.nih.gov/pubmed/35292784
http://dx.doi.org/10.1038/s41556-022-00852-9

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