CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH

Unlike most cell types, many cancer cells survive at low extracellular pH (pHe), a chemical signature of tumors. Genes that facilitate survival under acid stress are therefore potential targets for cancer therapies. We performed a genome-wide CRISPR-Cas9 cell viability screen at physiological and ac...

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Detalles Bibliográficos
Autores principales: Michl, Johanna, Wang, Yunyi, Monterisi, Stefania, Blaszczak, Wiktoria, Beveridge, Ryan, Bridges, Esther M., Koth, Jana, Bodmer, Walter F., Swietach, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924371/
https://www.ncbi.nlm.nih.gov/pubmed/35263578
http://dx.doi.org/10.1016/j.celrep.2022.110493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924371/
https://www.ncbi.nlm.nih.gov/pubmed/35263578
http://dx.doi.org/10.1016/j.celrep.2022.110493

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