Modeling Human Primary Microcephaly With hiPSC-Derived Brain Organoids Carrying CPAP-E1235V Disease-Associated Mutant Protein

The centrosome is composed of a pair of centrioles and serves as the major microtubule-organizing center (MTOC) in cells. Centrosome dysfunction has been linked to autosomal recessive primary microcephaly (MCPH), which is a rare human neurodevelopmental disorder characterized by small brain size wit...

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Detalles Bibliográficos
Autores principales: An, Hsiao-Lung, Kuo, Hung-Chih, Tang, Tang K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924525/
https://www.ncbi.nlm.nih.gov/pubmed/35309908
http://dx.doi.org/10.3389/fcell.2022.830432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924525/
https://www.ncbi.nlm.nih.gov/pubmed/35309908
http://dx.doi.org/10.3389/fcell.2022.830432

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