Targeting the lncRNA DUXAP8/miR-29a/PIK3CA Network Restores Doxorubicin Chemosensitivity via PI3K-AKT-mTOR Signaling and Synergizes With Inotuzumab Ozogamicin in Chemotherapy-Resistant B-Cell Acute Lymphoblastic Leukemia

PURPOSE: This study aimed to determine the expression profiles of long non-coding RNA (lncRNA), microRNA (miRNA), and mRNA in chemotherapy-resistant B-cell acute lymphoblastic leukemia (B-ALL). METHODS: LncRNA, miRNA, and mRNA profiles were assessed by RNA-seq in diagnostic bone marrow samples from...

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Detalles Bibliográficos
Autores principales: Zhang, Li, Zhou, Shixia, Zhou, Tiejun, Li, Xiaoming, Tang, Junling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924619/
https://www.ncbi.nlm.nih.gov/pubmed/35311115
http://dx.doi.org/10.3389/fonc.2022.773601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924619/
https://www.ncbi.nlm.nih.gov/pubmed/35311115
http://dx.doi.org/10.3389/fonc.2022.773601

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