Navigating Through Cell-Based In vitro Models Available for Prediction of Intestinal Permeability and Metabolism: Are We Ready for 3D?

Traditionally, in vitro studies to quantify the intestinal permeability of drugs have relied on two-dimensional cell culture models using human colorectal carcinoma cell lines, namely Caco-2, HT 29 and T84 cells. Although these models have been commonly used for high-throughput screening of xenobiot...

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Detalles Bibliográficos
Autores principales: Franco, Yesenia L., Da Silva, Lais, Cristofoletti, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925318/
https://www.ncbi.nlm.nih.gov/pubmed/34811603
http://dx.doi.org/10.1208/s12248-021-00665-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925318/
https://www.ncbi.nlm.nih.gov/pubmed/34811603
http://dx.doi.org/10.1208/s12248-021-00665-y

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