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A model for DHX15 mediated disassembly of A-complex spliceosomes

A critical step of pre-mRNA splicing is the recruitment of U2 snRNP to the branch point sequence of an intron. U2 snRNP conformation changes extensively during branch helix formation, and several RNA-dependent ATPases are implicated in the process. However, the molecular mechanisms involved remain t...

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Detalles Bibliográficos
Autores principales: Maul-Newby, Hannah M., Amorello, Angela N., Sharma, Turvi, Kim, John H., Modena, Matthew S., Prichard, Beth E., Jurica, Melissa S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925973/
https://www.ncbi.nlm.nih.gov/pubmed/35046126
http://dx.doi.org/10.1261/rna.078977.121