Structural dynamics determine voltage and pH gating in human voltage-gated proton channel

Voltage-gated proton (Hv) channels are standalone voltage sensors without separate ion conductive pores. They are gated by both voltage and transmembrane proton gradient (i.e., ∆pH), serving as acid extruders in most cells. Like the canonical voltage sensors, Hv channels are a bundle of four helices...

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Detalles Bibliográficos
Autores principales: Han, Shuo, Peng, Sophia, Vance, Joshua, Tran, Kimberly, Do, Nhu, Bui, Nauy, Gui, Zhenhua, Wang, Shizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926398/
https://www.ncbi.nlm.nih.gov/pubmed/35244539
http://dx.doi.org/10.7554/eLife.73093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8926398/
https://www.ncbi.nlm.nih.gov/pubmed/35244539
http://dx.doi.org/10.7554/eLife.73093

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